Progressive supranuclear palsy
Dementia, ataxia and parkinsonian symptoms.
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Disproportionate atrophy of the midbrain is seen with concavity of its superior and dorsolateral margins. Midline sagittal midbrain to pons area ratio is approximately 0.12 (the normal value is approximately 0.24).
Lacunar infarcts, discrete, confluent areas of ischemic demyelienation are seen in bilateral periventricular, deep and subcortical white matter.
Convexity sulci, lateral ventricles and surface of cerebellar folia are prominent – likely diffuse cerebral and cerebellar atrophy.