Xanthogranulomatous pyelonephritis (gross pathology)

Case contributed by A.Prof Frank Gaillard

Patient Data

Age: 35 years
Gender: Female

The specimen is received in OR and consistent with a resected kidney with abundant perirenal adipose tissue. The kidney is bivalved during intraoperative surgical pathology gross consultation. The dilated renal pelvis is filled with a large amount of pus material. The pus is sampled for culture. After washing the specimen, the walls of dilated calyces and renal pelvis are thickened with multiple yellow nodules. The renal cortex is largely atrophic.

Image courtesy of Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.. Please see case description page for licence and original file information. 

Sections through the yellow nodules show replacement of renal parenchyma with foamy histiocytes, occasional multinucleated giant cells, and inflammatory cells. The inflammatory cells are composed of lymphocytes, plasma cells, and neutrophils. Lymphoid aggregates are also noted. A few renal tubules are filled with cellular debris and possible bacterial clumps.​ Features are those of xanthogranulomatous pyelonephritis.

Image courtesy of Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.. Please see case description page for licence and original file information. 

Case Discussion

This is a case of xanthogranulomatous pyelonephritis in a 35-year-old female.

Author: Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.

Original file: PathXchange.org case here

Modifications: square crop

License: Image reproduced here with explicit permission of the author. All rights reserved by the author. Please refer to PathXchange.org case for further information.

If you believe your copyright or has been infringed please write to license@radiopaedia.org giving details of why you believe this is so.

PlayAdd to Share

Case information

rID: 9949
Published: 2nd Jun 2010
Last edited: 23rd Jun 2018
System: Urogenital
Inclusion in quiz mode: Excluded

Updating… Please wait.
Loadinganimation

Alert accept

Error Unable to process the form. Check for errors and try again.

Alert accept Thank you for updating your details.