Histopathology
MICROSCOPIC DESCRIPTION: The sections show features of a densely cellular astrocytic tumour. The tumour cells have elongated, angulated and hyperchromatic nuclei. Scattered mitotic figures are identified. There are foci of microvascular proliferation. Necrosis is absent. There is no evidence of oligodendroglial component. No lymphoma is seen. The features are those of glioblastoma. The tumour cells are p53 positive. The topoisomerase index is about 10%. IDH1-R132H immunostain is negative. MGMT is also negative (likely methylated). ATRX shows no loss of staining (non-mutated).
DIAGNOSIS: Left temporal periventricular tumour: Glioblastoma (WHO Grade IV), IDH-wildtype.