Sickle cell disease (abdominal manifestations)
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was changed:
Abdominal manifestations of sickle cell disease (SCD) are wide and can involve many organs.
For a general discussion, please refer to sickle cell disease.
Splenic
-
splenomegaly
- splenic enlargement may occur transiently with the sequestration syndrome, where rapid pooling of blood occurs in the spleen, resulting in intravascular volume depletion, with potential for cardiovascular collapse
-
autosplenectomy
- the slow, tortuous micro-circulation of the spleen renders it susceptible to infarction and subsequent functional asplenia
- 94% are asplenic by age 51
- radiological finding is of a
smallsmall, calcified spleen
- splenic abscesses
Hepatobiliary
- hepatic iron deposition secondary to multiple transfusions1
- hepatomegaly +/- coarsened echotexture with portal hypertension
- cholelithiasis +/- choledocholithiasis
- multiple liver abscesses
Renal
- kidneys are often large early in the disease, with variable echogenicity on ultrasound, but shrink with development of renal failure. Bilateral echogenic pyramids are frequently seen in sickle cell disease
- renal papillary necrosis
- renal vein thrombosis
Gastrointestinal tract
- approximately 40% patient may develop peptic ulcers due to reduced mucosal resistance and bowel ischaemia
See also
-<li>radiological finding is of a small, calcified spleen</li>- +<li>radiological finding is of a small, calcified spleen</li>
-<li>hepatic iron deposition secondary to multiple transfusions <sup>1</sup>- +<li>hepatic iron deposition secondary to multiple transfusions <sup>1</sup>
- +<li><a title="Renal vein thrombosis" href="/articles/renal-vein-thrombosis">renal vein thrombosis</a></li>
-<li><a href="/articles/chronic-lung-disease-in-sickle-cell-anaemia">acute chest syndrome in sickle cell disease</a></li>-<li><a href="/articles/chronic-lung-disease-in-sickle-cell-anaemia">chronic lung disease in sickle cell disease</a></li>- +<li><a href="/articles/sickle-cell-disease-chronic-lung-disease">acute chest syndrome in sickle cell disease</a></li>
- +<li><a href="/articles/sickle-cell-disease-chronic-lung-disease">chronic lung disease in sickle cell disease</a></li>
-<li><a href="/articles/cerebral-manifestations-of-sickle-cell-disease">cerebral manifestations of sickle cell disease</a></li>- +<li><a href="/articles/sickle-cell-disease-cerebral-manifestations">cerebral manifestations of sickle cell disease</a></li>
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