Cerebral cortical restricted diffusion

Last revised by Rohit Sharma on 5 Jan 2024

Cerebral cortical restricted diffusion, also known as gyriform restricted diffusion, cortical ribboning or cortical ribbon sign, refers to curvilinear hyperintense signal involving the cerebral cortex on DWI images with a corresponding low signal on ADC images.

Causes include the following disorders:

Vascular thrombo-occlusive disease (most common)
Haemodynamic changes
Infections
Metabolic 
Others

An acronym has been proposed to cover most of these disorders, which is "CRUMPLED" (Creutzfeldt-Jakob, Reversible cerebral vasoconstriction syndrome, Urea cycle disorders, Mitochondrial, Posterior reversible encephalopathy, Prolonged seizures, Laminar necrosis/hypoxic-ischaemic encephalopathy, Liver Disease, Encephalitis, and Diabetes) 5.

Cases and figures

  • Case 1: cortical venous thombosis
  • Case 2: rabies encephalitis
  • Case 3: Creutzfeldt-Jakob disease
  • Case 4 : postictal changes
  • Case 5: hepatic encephalopathy
  • Case 6: hypoglycaemic encephalopathy
  • Case 7: hypoxic-ischaemic encephalopathy
  • Case 8: methotrexate toxicity
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