Clear cell carcinoma of the cervix

Clear cell carcinoma of the cervix (CCCC) is a rare adenocarcinoma subtype of cervical cancer.

Due to association with diethylstilbestrol (DES) exposure in some patients, this subtype may have a younger age at presentation than other histological subtypes. This subtype can sometimes present in the paediatric age group 5.

The tumour can have solid, tubulocystic or papillary patterns 3.

Associations
  • there has been some association with in utero DES exposure in some patients ( ~6%) 2
  • unlike other types of cervical cancer, there is not thought to be any association with HPV DNA 4

In selected cases (particularly paediatric patients), radical trachelectomies have been carried out with fertility sparing 4-5.

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Article information

rID: 17794
System: Gynaecology
Tag: cases
Synonyms or Alternate Spellings:
  • Clear cell carcinoma of cervix
  • Cervical clear cell carcinoma
  • Cervical clear cell carcinoma (CCCC)

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