Thurston M, Tatco V, Kang O, et al. Clear cell carcinoma of the cervix. Reference article, Radiopaedia.org (Accessed on 19 Jan 2025) https://doi.org/10.53347/rID-17794
Due to association with diethylstilbestrol (DES) exposure in some patients, this subtype may have a younger age at presentation than other histological subtypes. This subtype can sometimes present in the pediatric age group 5.
Pathology
The tumor can have solid, tubulocystic or papillary patterns 3.
Associations
in utero DES exposure in some patients ( ~6%) 2
no association with HPV DNA (unlike other cervical cancer subtypes) 4
Treatment and prognosis
In selected cases (particularly pediatric patients), radical trachelectomies have been carried out with fertility sparing 4-5.
1. Hiromura T, Tanaka YO, Nishioka T et-al. Clear cell adenocarcinoma of the uterine cervix arising from a background of cervical endometriosis. Br J Radiol. 2009;82 (973): e20-2. doi:10.1259/bjr/75304693 - Pubmed citation
2. Thomas MB, Wright JD, Leiser AL et-al. Clear cell carcinoma of the cervix: a multi-institutional review in the post-DES era. Gynecol. Oncol. 2008;109 (3): 335-9. doi:10.1016/j.ygyno.2008.02.007 - Pubmed citation
3. Levine DA, Santos JF, Fleming GF. Handbook for Principles and Practice of Gynecologic Oncology. Lippincott Williams & Wilkins. (2010) ISBN:0781778484. Read it at Google Books - Find it at Amazon
5. Lester FC, Farmer DL, Rabban JT et-al. Radical trachelectomy for clear cell carcinoma of the cervix in a 6-year old: a case report, review, and description of the surgical technique. J. Pediatr. Surg. 2010;45 (8): E1-5. doi:10.1016/j.jpedsurg.2010.05.032 - Pubmed citation
5. Abu-rustum NR, Su W, Levine DA et-al. Pediatric radical abdominal trachelectomy for cervical clear cell carcinoma: a novel surgical approach. Gynecol. Oncol. 2005;97 (1): 296-300. doi:10.1016/j.ygyno.2004.12.050 - Pubmed citation
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