Cystic adventitial disease

Cystic adventitial disease (CAD) is an uncommon vascular pathology predominantly affecting peripheral vessels. The vast majority of cases occur in arteries with venous involvement being an even extremely rare occurrence 8.

It typically affects young to middle-aged individuals without evidence of atherosclerosis or other systemic vascular disease. There is a recognised male predilection with a M:F ratio of ~15:1 9

Although cystic adventitial disease can affect any peripheral vessel, there is a striking predilection in the popliteal region, affected in ~85% of cases 1,3-4.

Typical symptoms include:

  • rapidly progressive calf claudication 1,3 
  • lower extremity pain

The condition is characterised by a collection of mucinous material (mucous cysts) within adventitial wall of the affected vessel. 

Ultrasound

May show multiple anechoic to hypoechoic lesions within the affected arterial wall. Colour Doppler interrogation show no flow within the lesions. May also show associated arterial stenoses with relevant changes in arterial Doppler wave flow and velocity.

MRI

Appearances on MRI are variable, depending on the distribution and size of the cysts. 

May be seen as aggregates of multiple small round/ovoid masses originating in affected arterial wall, which if concentric lead to hourglass stenosis. When the lesions are large, they can have a multi-loculated appearance, and can displace the artery to one side - the so-called scimitar sign 4.  

Lesional signal characteristics include

  • T1: individual lesions are of variable signal dependent on mucoid content 4
  • T2/STIR: individual lesions are high signal 1,4
Angiography

Angiography may demonstrate curvilinear/spiral narrowing of vessels with a paucity of collaterals and an absence of poststenotic dilatation. When cystic lesions are large and eccentric they may displace the artery to one side - the so-called scimitar sign 4.

First described by H J Atkins and J A Key in 1947 4,5.

If in the classical popliteal location on angiography consider popliteal artery entrapment syndrome (PAES)

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Article Information

rID: 11042
Section: Pathology
Tag: cases
Synonyms or Alternate Spellings:
  • Adventitial cystic disease
  • Cystic adventitial disease (CAD)

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