Gastrointestinal neuroendocrine tumors

Gastrointestinal neuroendocrine tumours (GI NETS) can be functional or non-functional:

• functional NETS can be challenging to localise as: 
  • they are often small in size at the time of diagnosis 
  • arise in many sites throughout the body
• non-functioning and/or malignant NETs often are larger at presentation and therefore easier to locate

Pathology

Types of gastrointestinal - pancreatic neuroendocrine tumours

• insulinoma
  • account for 50% of pancreatic NETS
  • usually <2cm diameter          
  • 99% of insulinomas found in pancreas          
  • 10-15% are malignant 
• gastrinoma
  • account for 20-30% of pancreatic NETS
  • found in pancreas, lymph nodes and duodenum           
  • vary in size           
  • 60-75% are malignant 
• non functioning tumours and pancreatic polypeptide secreting tumours   
  • account for 15-20%           
  • almost exclusively found in pancreas          
  • usually malignant           
  • often large at presentation 
• vasoactive polypeptide secreting tumour (VIPoma)          
  • account for 3%           
  • 90% found in the pancreas          
  • 10% found in adrenal gland          
  • 50-60% are malignant 
• glucagonomas and somatostatinomas           
  • rare           
  • most commonly located in pancreas           
  • often malignant

Radiographic features

There is no consensus on the best single imaging modality for NETS and depends on the suspected location and local expertise. Combined modalities and techniques are often used ^1-3.

CT

• used for suspected gastric, enteric and pancreatic NETS pre and post IV iodinated contrast
• bowel distension with fluid, either by oral intake (CT enterography) or via a nasojejunal tube (CT enteroclysis) improves detection of primary GI NETS 

MRI

Used for suspected hepatic, pancreatic or retroperitoneal NETS, often with gadolinium contrast. MRI enterography also possible.

Ultrasound

• used for monitoring slow growing tumours and/or follow up of metastases. 
• ultrsoundultrasound can also be used to guide biopsies. 
• endoscopic or endoluminal/endoluminal US can be used to identify and characterised GI NETS as well as obtaining samples for cytology or histology

Nuclear medicine

• common radiopharmaceutical is 111-indium-pentetreotide, which is a ligand for somatostatin receptor on the cell membrane of many NETS ^4,5
• multiple tumour sites and/or metastasis can be identified using a gamma-camera to detect the emitted radiation 
• can be used in combination with cross-sectional imaging modalities to aid staging e.g. SPECT or PET-CT or PET-MRI ⁶
• can be used to predict response to nuclear medicine based therapies, and, in some cases, to assess response to treatment. 
• care should be taken with interpretation of images as drugs can interfere with somatostain receptor expression, e.g. interferon. 
• NETS can differentiate into tumours that do not express somatostatin receptors can become ‘image negative’ making reoccurrence or metastases more challenging to detect 
• other radiopharmaceuticals are also used, based on certain physiological characteristics e.g. cell surface receptors or uptake of molecules. 
  • gallium-68 labelled somatostatin analogues (PET/CT) – thought to be more sensitive in detecting NETS expect pulmonary and hepatic metastases 
  • for aggressive, rapidly growing tumours (i.e. high metabolism) Fluoro-di-glucose-PET/CT can be used (FDG-PET) 
  • F18 DOPA and C11 Hydroxytryptophan may be used in future but are not routinely available

Angiography

• venous sampling can be used in small functional NETS where cross sec-tional imaging is equivocal.
• multiple endocrine neoplasia type 1 can present with multiple lesions; functional NETS can be identified from these, using calcium stimulation with venous sampling. 
• angiography and endovascular procedures, such as trans-arterial chemo-embolization (TACE), can be used to treat hepatic metastases.

Practical points

Assessing specific gastrointetsinal NET imaging based on location

• gastric or colonic - endoscopy 
• small bowel
  • c-enhanced CT/MR enterography, +/- radiopharmaceuticals or gallium PET/CT to localize NETS as classically high concentration of Somatostatin receptors and are very vascular      
  • capsule endoscopy may be helpful to detect small bowel NETs not identified by CT or MRI but precise location difficult 
• pancreatic NETs   
  • non - functioning NETS present late and tend to be larger and have mass effect or non-specific symptoms or signs; these can be identified using CT.           
  • functioning NETs present early with signs and symptoms, leading to clinical suspicion of tumour which is often smaller and more challenging to locate                     
    • triple Phase thin multi-slice CT (pre-contrast/arterial/portal-venous)                     
    • high resolution MRI with T2, T1, fat saturated and dynamic contrast administration                     
    • PET 

Assessing malignancy and staging

Signs on CT of malignant NETs include ⁷

• larger size
• necrosis
• calcification
• invasion of the surrounding structures

Assessing metastases

• commonly metastases to lymph nodes and the liver, as well as bone, lung and mesentery 
• 40-80% of midgut NETs present with metastases at presentation. 
• union for International Cancer Control (UICC) TNM (tumour, node, metastasis) systems or the European Neuroendocrine Tumour Society (ENETS) have TNM staging systems which differ slightly from each other

See also

• endocrine tumours of the pancreas
• neuroendocrine tumours