Glucagonoma

Glucagonomas are pancreatic endocrine tumours that secrete glucagon. Most lesions are malignant.

They are rare with an incidence of 0.000005%. Equal incidence in middle-aged men and women. 

Most patients present with a necrolytic migratory rash and various other elements of the 4D syndrome which includes:

  • dermatitis / necrotizing migratory erythema
  • diabetes mellitus
  • deep vein thrombosis
  • depression

Stomatitis, diarrhoea, anaemia, and weight loss may also occur.

Plasma levels of glucagons are elevated (>500 pg ml).

Tumour size is variable, but most are large (>5 cm) and have metastasized at the time of diagnosis. Most are located in the distal pancreas and are vascular.

Tumors may be solid or contain central low-attenuation areas on CT.

Approximately 50% of patients survive at least 5 years after diagnosis.


Pancreatic pathology
Share article

Article Information

rID: 12911
Section: Pathology
Synonyms or Alternate Spellings:
  • Glucagonomas

Support Radiopaedia and see fewer ads

Updating… Please wait.
Loadinganimation

Alert accept

Error Unable to process the form. Check for errors and try again.

Alert accept Thank you for updating your details.