Neuroendocrine tumours

Neuroendocrine tumours (NET's) represent a large spectrum of disease. They consist of a large heterogeneous group of malignancies that are derived from embryonic neural crest tissue found in various organ such as the hypothalamus, pituitary gland, thyroid gland, adrenal medulla, and gastrointestinal tract. 

The spectrum of neuroendocrine turmours range from:


They can also be divided by their biochemical behaviour as functioning or non-functioning, by their aggressiveness as slow-growing and more aggressive lesions and so on.

Because of secretory products by amine precursor uptake and decarboxylation (APUD) they are also known as APUDomas, which is more historical and no longer used.


Mostly occur sporadically, some are linked to multiple endocrine neoplasia syndromes.

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Article information

rID: 28523
Tag: net
Synonyms or Alternate Spellings:
  • Neuroendocrine tumor
  • Neuroendocrine tumors
  • NET
  • APUD
  • Neuroendocrine tumours (NET's)
  • Neuroendocrine tumour (NET)
  • APUDomas

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