Hemochromatosis (skeletal manifestations)

Hemochromatosis is a systemic disease which affects many organs systems, including the joints, characterized by hemosiderin and calcium pyrophosphate deposition.

For a general discussion, and for links to other system specific manifestations, please refer to the article on hemochromatosis

  • chondrocalcinosis: particularly knees and triangular fibrocartilage
  • arthropathy
    • symmetrical loss of joint space, subchondral cysts 
    • close association with CPPD which is often seen concurrently
    • most commonly hands (MCP, carpal, PIP) with the characteristic hook like/ beak-like osteophytes projecting from radial ends of 2nd and 3rd metacarpals
      • more extensive involvement from the second to the fifth MCP and radial hook-like/drooping osteophytes are more characteristic than in CPPD 3

    • can also affect the knee, hip, and elbow  
  • generalized osteoporosis (~25%) or osteopaenia (~40%) 4

On imaging consider:

Article information

rID: 9721
Tag: refs, refs
Synonyms or Alternate Spellings:
  • Skeletal manifestations of haemochromatosis
  • Skeletal manifestations of hemochromatosis
  • Musculoskeletal manifestations of haemochromatosis
  • Musculoskeletal manifestations of hemochromatosis

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Cases and figures

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  • Case 2
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  • Case 3
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