Hopkins syndrome

Last revised by Daniel J Bell on 9 Dec 2022

Hopkins syndrome is a rare poliomyelitis-like neurological syndrome that occurs following an episode of acute asthma.

It usually manifests as flaccid paralysis of one or more limbs, several days or weeks following an episode of acute asthma.

The pathogenesis is unclear. Notably, many, but not all, case reports have identified many different viral triggers for the asthma attack 4.

  • T2: hyperintense anterior horn cell

  • T1+C (Gd): enhancement of the ventral nerve roots and anterior horn cell

Prognosis is usually not good and patients may remain paralyzed permanently, however, treatment with intravenous immunoglobulin with a good response has been reported in some cases 3.

The condition was first described by Ian James Hopkins (1934-2019), Australia's first pediatric neurologist, and Lloyd K Shield (fl. 2016), Australian pediatric neurologist, in their seminal 1974 case report 5.

ADVERTISEMENT: Supporters see fewer/no ads

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.