Hyperostosis of the skull has many causes, broadly divided into focal or diffuse.
Diffuse
- Paget disease of bone
- metastatic disease, especially prostate carcinoma
- chronic, severe anemia
- hyperparathyroidism
- acromegaly
- osteopetrosis
- hyperostosis frontalis interna
- long-term phenytoin use
- genetic diseases (rare)
Focal
- meningioma
- fibrous dysplasia
- Paget disease of bone
- metastatic disease, especially prostate carcinoma
- esthesioneuroblastoma: only rarely demonstrates hyperostosis
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