Last revised by Daniel J Bell on 30 Aug 2022

Hyperpyrexia, also known as hyperthermia, is a term reserved for very high fevers and is usually only deemed to be present when the core body temperature is >41.5°C 1,2.

Clinical presentation

Very high fevers appear to be markedly deleterious for cognitive wellbeing, patients often being delirious and mentally impaired with coma rapidly intervening in most cases without aggressive resuscitation.

Differential diagnosis

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