Hypogammaglobulinaemia is an immune disorder characterized by a reduction in all types of gammaglobulins. 

While hypogammaglobulinaemia means some of loss of gammaglobulins, a total loss is termed agammaglobulinaemia which can occur in as an x linked form - X-linked agammaglobulinemia.

The most commonly recognized clinical feature is recurrent infection (often respiratory). Increased incidence of parasitic gastrointestinal infections may also be present.

It may be primary of acquired.

There are decreased levels of immunoglobulins (especially IgG)

Features secondary to recurrent bronchopulmonary and sinus infections are common

These include

Article information

rID: 60149
Synonyms or Alternate Spellings:
  • Reduced gammaglobulins
  • Hypogammaglobulinemia

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