Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Yap J, Kennedy P, et al. Hypogammaglobulinaemia. Reference article, Radiopaedia.org (Accessed on 04 Mar 2025) https://doi.org/10.53347/rID-60149
Hypogammaglobulinaemia is an immune disorder characterized by a reduction in all types of gammaglobulins.
While hypogammaglobulinaemia means some loss of gammaglobulins, a total loss is termed agammaglobulinaemia which can occur as an X-linked form (X-linked agammaglobulinemia).
Associations
The most commonly recognized clinical feature is recurrent infection (often respiratory). Increased incidence of parasitic gastrointestinal infections may also be present.
Etiology
It may be primary or acquired.
Primary
Acquired
Markers
There are decreased levels of immunoglobulins (especially IgG).
ADVERTISEMENT: Supporters see fewer/no ads
Features secondary to recurrent bronchopulmonary and sinus infections are common. These include:
Chest
Abdomen
-
1. Glancy E, Siles R. Monoclonal B-cell lymphocytosis and hypogammaglobulinaemia. (2016) British journal of haematology. 173 (2): 316-7. doi:10.1111/bjh.13585 - Pubmed
-
2. Agarwal S, Cunningham-Rundles C. Treatment of hypogammaglobulinemia in adults: a scoring system to guide decisions on immunoglobulin replacement. (2013) The Journal of allergy and clinical immunology. 131 (6): 1699-701. doi:10.1016/j.jaci.2013.01.036 - Pubmed
-
3. Rose ME, Lang DM. Evaluating and managing hypogammaglobulinemia. (2006) Cleveland Clinic journal of medicine. 73 (2): 133-7, 140, 143-4. Pubmed
-
4. Norton KI, Som PM. Computed tomography findings in a case of hypogammaglobulinemia. (1986) The Journal of computed tomography. 10 (1): 41-3. Pubmed
-
5. Curtin JJ, Murray JG, Apthorp LA, Franz AM, Webster AD. Mediastinal lymph node enlargement and splenomegaly in primary hypogammaglobulinaemia. (1995) Clinical radiology. 50 (7): 489-91. Pubmed
-
6. Bierry G, Boileau J, Barnig C, Gasser B, Korganow AS, Buy X, Jeung MY, Roy C, Gangi A. Thoracic manifestations of primary humoral immunodeficiency: a comprehensive review. (2009) Radiographics : a review publication of the Radiological Society of North America, Inc. 29 (7): 1909-20. doi:10.1148/rg.297095717 - Pubmed
-
6. Curtin JJ, Webster AD, Farrant J, Katz D. Bronchiectasis in hypogammaglobulinaemia--a computed tomography assessment. (1991) Clinical radiology. 44 (2): 82-4. Pubmed
-
7. Roberts DM, Jones RB, Smith RM, Alberici F, Kumaratne DS, Burns S, Jayne DR. Rituximab-associated hypogammaglobulinemia: incidence, predictors and outcomes in patients with multi-system autoimmune disease. (2015) Journal of autoimmunity. 57: 60-5. doi:10.1016/j.jaut.2014.11.009 - Pubmed
-
8. Obregon RG, Lynch DA, Kaske T, Newell JD, Kirkpatrick CH. Radiologic findings of adult primary immunodeficiency disorders. Contribution of CT. (1994) Chest. 106 (2): 490-5. Pubmed
Promoted articles (advertising)
Unable to process the form. Check for errors and try again.
