Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Yap J, Kennedy P, et al. Hypogammaglobulinaemia. Reference article, Radiopaedia.org (Accessed on 04 Mar 2025) https://doi.org/10.53347/rID-60149
Hypogammaglobulinaemia is an immune disorder characterized by a reduction in all types of gammaglobulins.
While hypogammaglobulinaemia means some loss of gammaglobulins, a total loss is termed agammaglobulinaemia which can occur as an X-linked form (X-linked agammaglobulinemia).
Associations
The most commonly recognized clinical feature is recurrent infection (often respiratory). Increased incidence of parasitic gastrointestinal infections may also be present.
Etiology
It may be primary or acquired.
Primary
Acquired
Markers
There are decreased levels of immunoglobulins (especially IgG).
Features secondary to recurrent bronchopulmonary and sinus infections are common. These include:
Chest
Abdomen
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