IgA nephropathy (also known as IgA nephritis or Berger disease) is a form of glomerulonephritis.
Primary IgA nephropathy is characterised by deposition of IgA antibodies in the glomeruli. The is thought to start with defective glycosylation of IgA subclass IgA1 that results in overproduction of galactose-deficient IgA1 (Gd-IgA1), occurrence of anti-Gd-IgA1 autoantibodies, and mesangial deposition of nephritogenic immune complexes. This may eventually lead to increased mesangial cell proliferation, inflammatory responses, and complement activation.
The most common associatation is a IgA vasculitis (which is often considered a broader systemic form of IgA nephropathy.
- macroscopic haematuria in conjunction with respiratory or gastrointestinal infection (common presentation in younger patients)
- microscopic haematuria
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