IgA nephropathy

IgA nephropathy (also known as IgA nephritis or Berger disease) is a form of glomerulonephritis

IgA nephropathy is considered the most common glomerulonephritis worldwide and is a leading cause of chronic kidney disease and renal failure.

Primary IgA nephropathy is characterised by deposition of  IgA antibodies in the glomeruli. The is thought to start with defective glycosylation of IgA subclass IgA1 that results in overproduction of galactose-deficient IgA1 (Gd-IgA1), occurrence of anti-Gd-IgA1 autoantibodies, and mesangial deposition of nephritogenic immune complexes. This may eventually lead to increased mesangial cell proliferation, inflammatory responses, and complement activation.

The most common associatation is a IgA vasculitis (which is often considered a broader systemic form of IgA nephropathy.

  • macroscopic haematuria in conjunction with respiratory or gastrointestinal infection (common presentation in younger patients)
  • microscopic haematuria
  • proteinuria
  • hypertension
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Article information

rID: 52280
System: Urogenital
Synonyms or Alternate Spellings:
  • IgA nephritis
  • Berger disease
  • Immunoglobulin A nephropathy (IgAN)

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