Long-term epilepsy-associated tumors (LEATs) is a pragmatic grouping of varied primary brain tumors that share a number of features including slow indolent growth rate, localization to the cortex and a predilection for the temporal lobe.
These characteristics combine to make them a common cause of early-onset drug-resistant epilepsy 1. As they are not a histopathologically defined entity, the members of LEAT are somewhat variable across publications but invariably include the following two entities that account for the majority of cases:
gangliogliomas and gangliocytomas (similar but uncommon)
Additionally, depending on the publication, other entities are often included 1-3,5:
It is important to note that many other tumors not included in this list also cause seizures, however, due to their speed of growth and demographics they tend to be identified and treated shortly after treatment onset (e.g. cerebral metastasis, astrocytoma, oligodendroglioma, glioblastoma).
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