Mannose-binding lectin (MBL) deficiency is a condition that affects the immune system.
It may be prevalent in 10-30% of the general population (dependant on the definition used).
Affected individuals have low levels of an immune protein named mannose-binding lectin in their blood. They are prone to recurrent infections, including infections of the upper respiratory tract and other body systems.
- 1. Chalmers JD, McHugh BJ, Doherty C et-al. Mannose-binding lectin deficiency and disease severity in non-cystic fibrosis bronchiectasis: a prospective study. Lancet Respir Med. 2013;1 (3): 224-32. doi:10.1016/S2213-2600(13)70001-8 - Pubmed citation
- 2. van Kessel DA, Hoffman TW, van Velzen-Blad H et-al. Response to pneumococcal vaccination in mannose-binding lectin-deficient adults with recurrent respiratory tract infections. Clin. Exp. Immunol. 2014;177 (1): 272-9. doi:10.1111/cei.12299 - Free text at pubmed - Pubmed citation
- 3. Aydin SZ, Atagunduz P, Inanc N et-al. Mannose binding lectin levels in spondyloarthropathies. J. Rheumatol. 2007;34 (10): 2075-7. J. Rheumatol. (abstract) - Pubmed citation