Mannose-binding lectin deficiency

Mannose-binding lectin (MBL) deficiency is a condition that affects the immune system.

Epidemiology

It may be prevalent in 10-30% of the general population.

Pathology

Affected individuals have low levels of an immune protein named mannose-binding lectin in their blood. They are prone to recurrent infections, including infections of the upper respiratory tract and other body systems.

Associations
  • disease progression in cystic fibrosis 1
  • severe disease in those with bronchiectasis without underlying cystic fibrosis
  • more severe progression in those with spondyloarthropathies such as ankylosing spondylitis 3
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Article information

rID: 31652
System: Haematology
Synonyms or Alternate Spellings:
  • MBL deficiency
  • Mannose-binding lectin (MBL) deficiency
  • MBL2 deficiency
  • MBP deficiency
  • Mannose-binding protein deficiency

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