Melkersson-Rosenthal syndrome (MRS), also known as cheilitis granulomatosa or Miescher-Melkersson-Rosenthal Syndrome, is a rare condition of unknown aetiology characterised by:
- granulomatous inflammation of the face and lips (non-caseating)
- facial nerve (CN VII) paralysis (involvement of cranial nerves II, VIII, IX and XII have also been reported)
- plication of the tongue
All three findings are only seen in about 25% of cases, with orofacial oedema being the dominant finding and presenting sign in 42% of cases.
The facial palsy in MRS, which typically occurs after the onset of oedema (although preceding has been reported) is of the lower motor-neuron type and is seen in approximately 30% of patients. It may be complete or partial, unilateral or bilateral, transient or permanent.
Imaging findings are confined to confirming preseptal orbital oedema.
- 1. Cockerham KP, Hidayat AA, Cockerham GC et-al. Melkersson-Rosenthal syndrome: new clinicopathologic findings in 4 cases. Arch. Ophthalmol. 2000;118 (2): 227-32. - Pubmed citation
- 2. Van de scheur MR, Van der waal RI, Van bodegraven AA et-al. Cheilitis granulomatosa and optic neuropathy as rare extraintestinal manifestations of Crohn's disease. J. Clin. Gastroenterol. 34 (5): 557-9. J. Clin. Gastroenterol. (link) - Pubmed citation
- 3. Cabrera-gómez JA, Echazabal-santana N, Real-gonzález Y et-al. Hereditary Melkersson-Rosenthal syndrome and multiple sclerosis. Mult. Scler. 2005;11 (3): 364-6. Mult. Scler. (link) - Pubmed citation