Morvan syndrome, also known as Morvan fibrillary chorea, is a rare syndrome thought to be either paraneoplastic or autoimmune in origin.
It is characterised by:
- weight loss
- severe insomnia
Voltage gated potassium channel (VGKC) antibodies are frequently present in this syndrome.
History and etymology
The condition is named after the French physician, Augustin Marie Morvan (1819-1897) who first described it in 1890 3,4.
- 1. Liguori R, Vincent A, Clover L et-al. Morvan's syndrome: peripheral and central nervous system and cardiac involvement with antibodies to voltage-gated potassium channels. Brain. 2001;124 (Pt): 2417-26. Brain (link) - Pubmed citation
- 2. Hudson LA, Rollins YD, Anderson CA et-al. Reduplicative paramnesia in Morvan's syndrome. J. Neurol. Sci. 2008;267 (1-2): 154-7. doi:10.1016/j.jns.2007.09.030 - Pubmed citation
- 3. Morvan A. De la chorée fibrillaire. Gazette Hebdomadaire de Mèdicine et de Chirurgie. 1890;27:173-200.
- 4. El-Bitar MK, Muwakkit SA, Abboud MR, Sawaya RA, Boustany RM. Morvan syndrome following B-cell lymphoma. (2010) Journal of child neurology. 25 (8): 1038-41. doi:10.1177/0883073809356108 - Pubmed