Multilayered periosteal reaction
Citation, DOI, disclosures and article data
Citation:
Amini B, Sharma R, Knipe H, et al. Multilayered periosteal reaction. Reference article, Radiopaedia.org (Accessed on 22 Mar 2025) https://doi.org/10.53347/rID-1697
rID:
1697
Article created:
2 May 2008,
Behrang Amini
Disclosures:
At the time the article was created Behrang Amini had no recorded disclosures.
View Behrang Amini's current disclosures
Last revised:
Disclosures:
At the time the article was last revised Rohit Sharma had no financial relationships to ineligible companies to disclose.
View Rohit Sharma's current disclosures
Revisions:
15 times, by
10 contributors -
see full revision history and disclosures
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Synonyms:
- Onion skin periosteal reaction
- Lamellated periosteal reaction
Multilayered periosteal reaction, also known as a lamellated or onion skin periosteal reaction, demonstrates multiple concentric parallel layers of new bone adjacent to the cortex, reminiscent of the layers on an onion. The layers are thought to be the result of periods of variable growth 2 and indicate a pathological process of intermediate aggressiveness.
Pathology
It has been associated with:
- osteosarcoma
- acute osteomyelitis
- Ewing sarcoma
- Langerhans cell histiocytosis (LCH)
- hypertrophic osteoarthropathy
See also
Quiz questions
References
- 1. Wenaden AE, Szyszko TA, Saifuddin A. Imaging of periosteal reactions associated with focal lesions of bone. Clin Radiol. 2005;60 (4): 439-56. doi:10.1016/j.crad.2004.08.017 - Pubmed citation
- 2. Roche CJ, O'Keeffe DP, Lee WK et-al. Selections from the buffet of food signs in radiology. Radiographics. 22 (6): 1369-84. doi:10.1148/rg.226025521 - Pubmed citation
Incoming Links
Articles:
- Describing a bone lesion
- Fibrosarcoma of the bone
- Codman triangle periosteal reaction
- Aggressive vs non-aggressive bone lesions (radiographs)
- Vegetable and plant inspired signs
- Periosteal reaction
- Ewing sarcoma of the chest wall
- Onion sign (disambiguation)
- Osteosarcoma
- Ewing sarcoma
- Solid periosteal reaction
Cases:
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