Nodule-in-nodule appearance (liver)

In hepatic imaging, a nodule-in-nodule appearance represents foci of abnormal arterial enhancement within a liver lesion, in cases of a liver regenerative nodule with a focus of hepatocellular carcinoma or high-grade dysplastic nodule. It is so called because of the nodular arterial enhancement is seen within the main non-enhancing liver nodule (at least in arterial phase).

It may be seen in up to 6% of patients with dysplastic nodules 1.

Article information

rID: 26033
Section: Signs
Synonyms or Alternate Spellings:
  • Nodule-in-nodule sign
  • Nodule-in-nodule appearance
  • Nodule in a nodule appearance
  • Nodule in a nodule sign

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Cases and figures

  • Case 1: pre contrast
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  • Case 1: post contrast
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