St-Amant M, Tatco V, Di Muzio B, et al. Nodule-in-nodule appearance (liver). Reference article, Radiopaedia.org (Accessed on 11 Mar 2025) https://radiopaedia.org/articles/26033
In hepatic imaging, a nodule-in-nodule appearance represents foci of abnormal arterial enhancement within a liver lesion, in cases of a liver regenerative nodule with a focus of hepatocellular carcinoma or high-grade dysplastic nodule. It is so called because of the nodular arterial enhancement is seen within the main non-enhancing liver nodule (at least in arterial phase).
It may be seen in up to 6% of patients with dysplastic nodules 1.
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