Ophelia syndrome
Citation, DOI, disclosures and article data
Citation:
Gaillard F, Sharma R, Ophelia syndrome. Reference article, Radiopaedia.org (Accessed on 01 Mar 2025) https://doi.org/10.53347/rID-51568
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rID:
51568
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Disclosures:
At the time the article was created Frank Gaillard had no recorded disclosures.
View Frank Gaillard's current disclosures
Last revised:
Disclosures:
At the time the article was last revised Rohit Sharma had no financial relationships to ineligible companies to disclose.
View Rohit Sharma's current disclosures
Revisions:
2 times, by
2 contributors -
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Ophelia syndrome is the association of Hodgkin lymphoma with an autoimmune limbic encephalitis, as a result of anti-metabotropic glutamate receptor 5 antibodies (mGluR5) 1. In addition to anti-mGluR5, many other antibodies are associated with or implicated in autoimmune encephalitis in the setting of Hodgkin lymphoma 2.
References
- 1. Kelley BP, Patel SC, Marin HL, Corrigan JJ, Mitsias PD, Griffith B. Autoimmune Encephalitis: Pathophysiology and Imaging Review of an Overlooked Diagnosis. AJNR. American journal of neuroradiology. doi:10.3174/ajnr.A5086 - Pubmed
- 2. Soto-Rincón C, Castillo-Torres S, Cantú-García D, Estrada-Bellmann I, Chávez-Luévanos B, Marfil A. The Poor Insane Ophelia: Reconsidering Ophelia Syndrome. Arq Neuropsiquiatr. 2019;77(11):828-31. doi:10.1590/0004-282X20190105 - Pubmed
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