Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Silverstone L, Chieng R, Perilobular fibrosis. Reference article, Radiopaedia.org (Accessed on 20 Mar 2025) https://doi.org/10.53347/rID-171787
Perilobular fibrosis is a pattern of pulmonary fibrosis along the peripheral septa of secondary pulmonary lobules and is a typical feature in some cases of organizing pneumonia 5 and eosinophilic pneumonia 7.
Pathology
Organizing pneumonia is a common response to lung injury and the histological correlate is polypoid fibroblastic aggregations plugging alveolar sacs, ducts and bronchioles, which typically accompanies other disease such as pneumonia, collagen vascular disease, hypersensitivity pneumonitis, medication-induced lung injury, aspiration pneumonitis, etc 6.
Radiographic features
CT
Perilobular fibrosis is seen as fuzzy peripheral arcades along the visceral pleura (arcade-like sign) or fuzzy curvilinear bands of increased attenuation 5.
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2. Chiarenza A, Esposto Ultimo L, Falsaperla D et al. Chest Imaging Using Signs, Symbols, and Naturalistic Images: A Practical Guide for Radiologists and Non-Radiologists. Insights Imaging. 2019;10(1):114. doi:10.1186/s13244-019-0789-4 - Pubmed
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3. Ujita M, Renzoni E, Veeraraghavan S, Wells A, Hansell D. Organizing Pneumonia: Perilobular Pattern at Thin-Section CT. Radiology. 2004;232(3):757-61. doi:10.1148/radiol.2323031059 - Pubmed
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4. Palmucci S, Galioto F, Fazio G et al. Clinical and Radiological Features of Lung Disorders Related to Connective-Tissue Diseases: A Pictorial Essay. Insights Imaging. 2022;13(1):108. doi:10.1186/s13244-022-01243-2 - Pubmed
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5. Bankier A, MacMahon H, Colby T et al. Fleischner Society: Glossary of Terms for Thoracic Imaging. Radiology. 2024;310(2):e232558. doi:10.1148/radiol.232558 - Pubmedw
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6. Kligerman S. Pathogenesis, Imaging, and Evolution of Acute Lung Injury. Radiol Clin North Am. 2022;60(6):925-39. doi:10.1016/j.rcl.2022.06.005 - Pubmed
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7. Carbone R, Puppo F, Mattar E, Roden A, Hirani N. Acute and Chronic Eosinophilic Pneumonia: An Overview. Front Med. 2024;11:1355247. doi:10.3389/fmed.2024.1355247 - Pubmed
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