Primary fallopian tube carcinoma (PFTC) is an extremely rare malignancy that arises from the fallopian tube. They account for ~1 (0.2-1.1)% all gynecological malignancies (least common of all gynecological malignancies 3).
The estimated incidence is at ~3-4 per million women 3. It typically present in post menopausal females (peaks at 6th-7th decades).
Most patients are asymptomatic or tend to present with non specific or insiduous symptoms. The symptoms complex comprising of an intermittent profuse serosanguineous vaginal discharge, colicky lower abdomino-pelvic pain relieved by the vaginal discharge, and an adnexal mass can be present in ~15% of and is termed the Latzko triad 13-14.
Most primary fallopian tube cancers arise from ampulla with endoluminal growth that leads to obstruction and distension of the fallopian tube (hydrosalpinx), which explains why the majority of these patients are rarely asymptomatic in contrast with those with ovarian cancer.
Tumors can be bilateral in 20% of the cases, mainly in advanced disease.
The pattern of growth can be nodular, papillary, infiltrative, or mass forming.
Recognized histological types include:
papillary serous adenocarcinoma of fallopian tube
- most common histological sub type
- can be histologically identical to a serous cystadenocarcinoma of the ovary.
- endometrioid carcinoma of the fallopian tube
- transitional cell carcinoma of the fallopian tube
The tumor usually originates in the ampulla of the Fallopian tube. Bilateral involvement can in been is ~20% of cases 1.
Serum CA-125 levels often elevated 6,8
Advanced tumors are difficult to differentiate from ovarian tumors on imaging. The presence of a hydrosalpinx can be a useful feature.
While being non specific, it may be sonographically identified as a complex cystic mass involving the fallopian tube with papillary projections 10-11.
More content required
While signal characteristics are not specific, they generally are as follows 1,3
- solid tumor portion is usually of low signal
- if there is an associated simple serous fluid containing hydrosalpinx this may be low signal
- if there is an associated simple hemorrhagic fluid containing hydrosalpinx this may be high signal
- solid tumor component is often homogeneously or heterogeneously low or of intermediate signal
- if there is an associated simple serous fluid containing hydrosalpinx this may be of high signal
- T1 C+ (Gd): solid portion often demonstrates enhancement
Treatment and prognosis
Compared with ovarian carcinoma, fallopian tube cancer more tends to present at an earlier stage but has a worse prognosis, stage for stage 2. The reposted better overall survival therefore may be on the basis of earlier stage at presentation 4. Treatment generally consists of surgical debulking followed by chemotherapy.
For a mass involving the fallopian tube, differential considerations would be:
- 1. Rezvani M, Shaaban AM. Fallopian tube disease in the nonpregnant patient. Radiographics. 31 (2): 527-48. doi:10.1148/rg.312105090 - Pubmed citation
- 2. Nikrui N, Duska LR. Fallopian tube carcinoma. Surg. Oncol. Clin. N. Am. 1998;7 (2): 363-73. - Pubmed citation
- 3. Kim MY, Rha SE, Oh SN et-al. MR Imaging findings of hydrosalpinx: a comprehensive review. Radiographics. 29 (2): 495-507. doi:10.1148/rg.292085070 - Pubmed citation
- 4. Ajithkumar TV, Minimole AL, John MM et-al. Primary fallopian tube carcinoma. Obstet Gynecol Surv. 2005;60 (4): 247-52. Obstet Gynecol Surv (link) - Pubmed citation
- 5. Osmanağaoğlu MA, Bozkaya H, Cobanoğlu U. Primary adenocarcinoma of the fallopian tube: a case report. Eur. J. Gynaecol. Oncol. 2004;25 (6): 755-8. - Pubmed citation
- 6. Baekelandt M, Jorunn nesbakken A, Kristensen GB et-al. Carcinoma of the fallopian tube. Cancer. 2000;89 (10): 2076-84. Cancer (link) - Pubmed citation
- 7. Pectasides D, Pectasides E, Economopoulos T. Fallopian tube carcinoma: a review. Oncologist. 2006;11 (8): 902-12. doi:10.1634/theoncologist.11-8-902 - Pubmed citation
- 8. Kuscu E, Oktem M, Haberal A et-al. Management of advanced-stage primary carcinoma of the fallopian tube: case report and literature review. Eur. J. Gynaecol. Oncol. 2003;24 (6): 557-60. - Pubmed citation
- 9. Schneider C, Wight E, Perucchini D et-al. Primary carcinoma of the fallopian tube. A report of 19 cases with literature review. Eur. J. Gynaecol. Oncol. 2000;21 (6): 578-82. - Pubmed citation
- 10. Kurjak A, Kupesic S, Jacobs I. Preoperative diagnosis of the primary fallopian tube carcinoma by three-dimensional static and power Doppler sonography. Ultrasound Obstet Gynecol. 2000;15 (3): 246-51. doi:10.1046/j.1469-0705.2000.00080.x - Pubmed citation
- 11. Ko ML, Jeng CJ, Chen SC et-al. Sonographic appearance of fallopian tube carcinoma. J Clin Ultrasound. 2005;33 (7): 372-4. doi:10.1002/jcu.20138 - Pubmed citation
- 12. Kol S, Gal D, Friedman M et-al. Preoperative diagnosis of fallopian tube carcinoma by transvaginal sonography and CA-125. Gynecol. Oncol. 1990;37 (1): 129-31. - Pubmed citation
- 13. Callahan TL, Caughey AB. Blueprints Obstetrics and Gynecology. Lippincott Williams & Wilkins. (2008) ISBN:078178249X. Read it at Google Books - Find it at Amazon
- 14. Gibbs RS, Danforth DN, Karlan BY et-al. Danforth's obstetrics and gynecology. Lippincott Williams & Wilkins. (2008) ISBN:078176937X. Read it at Google Books - Find it at Amazon