Renal hemosiderosis results from accumulation of hemosiderin in the kidneys. It is usually considered a benign and incidental radiologic finding and rarely results in clinically apparent renal dysfunction.
Renal hemosiderosis is a known complication of the following conditions:
- chronic intravascular hemolytic states such as hemolytic anemias like sickle cell anemia and thalassemia 1,3
- paroxysmal nocturnal hemoglobinuria (PNH)
- mechanical hemolysis from prosthetic cardiac valve
No focal abnormalities usually seen on CT.
The kidneys exhibit abnormally low renal cortical signal in T1W and T2W sequences on MRI.
General imaging differential considerations include
- 1. Jeong JY, Kim SH, Lee HJ et-al. Atypical low-signal-intensity renal parenchyma: causes and patterns. Radiographics. 2002;22 (4): 833-46. Radiographics (full text) - Pubmed citation
- 2. Queiroz-Andrade M, Blasbalg R, Ortega CD et-al. MR imaging findings of iron overload. Radiographics. 2009;29 (6): 1575-89. Radiographics (full text) - doi:10.1148/rg.296095511 - Pubmed citation
- 3. Buhl L, Muirhead DE, Prentis PF. Renal hemosiderosis due to thalassemia: a light and electron microscopy study with electron probe X-ray microanalysis. Ultrastruct Pathol. 1993;17 (2): 169-83. Pubmed citation