Retroperitoneal liposarcoma
Updates to Article Attributes
Body
was changed:
Retroperitoneal liposarcoma is a subtype of liposarcoma, and is a malignant tumour of mesenchymal origin that may arise in any fat-containing region of the body. It is one of the most common primary retroperitoneal neoplasms 2.
Pathology
Histology
There are five histological types:
- well-differentiated: ~55%, low grade
- lipoma-like
- inflammatory
- sclerosing
- myxoid: ~30%, low-to-intermediate grade
- pleomorphic: high grade
- round cell: high grade
- dedifferentiated: high grade
Metastatic disease is haematogenous and the extent of metastases is related to the histological grade of the tumour.
Radiographic features
CT
- heterogenous mass
- varying amount of fat and soft tissue
- multiple septae
- enhancing soft tissue components
MRI
- myxoid: hyperintense on T2WI with delayed post-contrast enhancement
Treatment and prognosis
The primary treatment option is resection if possible. However, local recurrence is common and occurs in two-thirds of patients. This is usually a sign of incomplete resection and highlights the difficulty in discriminating liposarcomas from normal retroperitoneal fat.
Differential diagnosis
- retroperitoneal leiomyosarcoma
- retroperitoneal malignant fibrous histiocytoma
- retroperitoneal fibrosarcoma
- exophytic renal angiomyolipoma (AML)
- presence of a large vessel extending into the renal cortex suggestive of AML; liposarcomas are hypovascular
- renal parenchymal defect at the site of tumour contact strongly favours the diagnosis of exophytic angiomyolipoma
- calcifications suggest liposarcoma 3
-<li><a href="/articles/retroperitoneal-malignant-fibrous-histiocytoma">retroperitoneal malignant fibrous histiocytoma</a></li>- +<li><a href="/articles/malignant-fibrous-histiocytoma-of-the-retroperitoneum-1">retroperitoneal malignant fibrous histiocytoma</a></li>
Images Changes:
Image 7 CT (C+ portal venous phase) ( create )
