Schiller-Duval body (histology)

Schiller-Duval body is a perivascular structure that can be found in 50% of testicular yolk sac tumors also known as endodermal sinus tumors. If present it is considered pathognomonic. 


A central vessel is surrounded by tumor cells, and the cell-vessel complex is contained in a cystic space, often lined by flattened tumor cells. It represents an attempt to form yolk sacs. The cell-vessel complex is said to resemble a glomerulus.

Immunofluorescent staining may reveal eosinophilic hyalin-like globules both inside and outside the cytoplasm. The globules contain contain AFP and alpha 1-antitrypsin.

History and etymology

It is named after Mathias-Marie Duval (1844-1907), French professor of anatomy and histology, and Walter Schiller (1887-1960), Austrian-born American pathologist.

Article information

rID: 27970
System: Urogenital
Section: Pathology
Synonyms or Alternate Spellings:
  • Schiller-Duval bodies

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Cases and figures

  • Figure 1: histology
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