Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Bell D, Knipe H, et al. Sperm cell granuloma. Reference article, Radiopaedia.org (Accessed on 24 Feb 2025) https://doi.org/10.53347/rID-35634
Sperm cell granulomas, also called epididymitis nodosa, are benign lesions that can occur in the scrotum; particularly, in those with a prior vasectomy.
They occur after vasectomy in up to 40% of patients 2.
It is considered a form of chronic epididymitis which occurs secondary to inflammation, trauma, and/or a vasectomy. A granulomatous reaction forms secondary to extravasated sperm cells
Ultrasound
It may appear as a well-circumscribed heterogeneous mass and is commonly found at the epididymis or the ends of the divided ductus deferens.
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1. Frates MC, Benson CB, DiSalvo DN et-al. Solid extratesticular masses evaluated with sonography: pathologic correlation. Radiology. 1997;204 (1): 43-6. doi:10.1148/radiology.204.1.9205221 - Pubmed citation
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2. Dogra VS, Gottlieb RH, Oka M et-al. Sonography of the scrotum. Radiology. 2003;227 (1): 18-36. Radiology (full text) - doi:10.1148/radiol.2271001744 - Pubmed citation
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3. Garrido-Abad P, Díaz-Menéndez A, García-Martín L, Senra-Bravo I, Fernández-Arjona M. Tumor-Like Appearance of Spermatic Granuloma. Int Braz J Urol. 2019;45(3):634-6. doi:10.1590/S1677-5538.IBJU.2018.0676 - Pubmed
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4. Lv D, Xie H, Cui F, Zhou H, Shuang W. Bilateral Occurrence of Sperm Granulomas in the Left Spermatic Cord and on the Right Epididymis: A Case Report. World J Clin Cases. 2022;10(29):10787-93. doi:10.12998/wjcc.v10.i29.10787 - Pubmed
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