Subcutaneous rheumatoid nodules
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At the time the article was created Vinicius Carraro do Nascimento had no recorded disclosures.View Vinicius Carraro do Nascimento's current disclosures
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Subcutaneous rheumatoid nodules are the most common extra-articular manifestation of rheumatoid arthritis, occurring in up to 40% of patients. They are universally associated with a positive rheumatoid factor (RF) 1.
The size of the nodules varies from 2 mm to 5 cm; they are firm, non-tender, and movable in subcutaneous tissue 2. They usually are seen in the subcutaneous plane of the forearm, elbows, occiput, and lumbosacral area 3.
Rheumatoid nodules are characterized histologically by a core of fibrinoid necrosis with surrounding palisading histiocytes and granulation tissue.
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