Tc-99m DMSA
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View Jeremy Jones's current disclosuresAt the time the article was last revised Ammar Ashraf had no financial relationships to ineligible companies to disclose.
View Ammar Ashraf's current disclosures- DMSA
- Technetium-99m dimercaptosuccinic acid (DMSA)
- Technetium-99m dimercaptosuccinic acid
- Technetium-99m DMSA
Tc-99m DMSA (2,3 dimercaptosuccinic acid) is a technetium radiopharmaceutical used in renal imaging to evaluate renal structure and morphology, particularly in paediatric imaging for detection of scarring and pyelonephritis. DMSA is an ideal agent for assessment of the renal cortex as it binds to the sulfhydryl groups in proximal tubules at the renal cortex with longer retention than other agents. This results in higher concentration and hence much higher resolution with pinhole SPECT. Also, it allows better assessment of differential renal function. It is a static scan as opposed to dynamic DTPA or MAG3 scans.
Characteristics
photon energy: 140 keV
physical half-life: 6 hours
biological half-life: 2.5-3.5 hours
2.3 < pH < 3.5 3,4
normal distribution: kidneys (100%)
excretion: renal
target organ: kidneys
-
pharmacokinetics:
after the injection 90% of the 2,3 dimercaptosuccinic acid is bound to plasma proteins 3,4
40-50% fixed to cortex (greater than glucoheptonate)
maximal cortical uptake within 3 hours
-
miscellaneous facts:
high-resolution imaging with pinhole collimators and SPECT is not possible with DTPA, MAG3 or OIH because of rapid transit times
diseases affecting the proximal convoluted tubules such as renal tubular acidosis, Fanconi syndrome and nephrotoxic drugs such as gentamicin and cisplatin also inhibit the DMSA uptake
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Uses, doses and timings
Renal cortical imaging
References
- 1. Ziessman HA, O'Malley JP, Thrall JH. Nuclear medicine. Saunders. ISBN:0323082998. Read it at Google Books - Find it at Amazon
- 2. Gelfand MJ, Parisi MT, Treves ST. Pediatric radiopharmaceutical administered doses: 2010 North American consensus guidelines. (2011) Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 52 (2): 318-22. doi:10.2967/jnumed.110.084327 - Pubmed
- 3. M. P. Natale. P&C 5.1. Tecnico di radiologia. Guida completa alla preparazione di test preselettivi e prove pratiche per TSRM. Con software di simulazione. (2019) ISBN: 9788865846483
- 4. Maurizio Dondi, Raffaele Giubbini. Medicina nucleare nella pratica clinica. Con CD-ROM. (2019) ISBN: 9788855527286
Incoming Links
- Crossed renal ectopia
- Renal scarring (DMSA scan)
- Pelvic kidney
- Unilateral renal agenesis
- Unilateral renal agenesis
- Primary renal lymphoma
- Cross fused renal ectopia
- Crossed fused renal ectopia
- Transitional cell carcinoma of the ureter
- Horseshoe kidney
- Renal cortical scarring
- Normal DMSA scan
- Non-functioning kidney (DMSA scan)
- Crossed fused renal ectopia
- Horseshoe kidney
- Multicystic dysplastic kidney
- Ectopic kidney
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