This case demonstrates a pathology-proven ascending colon schwannoma.

Gastrointestinal schwannomas are extremely rare mesenchymal neoplasms, typically present at about the 3rd to 5th decades of life. Patients are often asymptomatic but may occasionally present with abdominal discomfort or rarely GI bleeding. The stomach is the most common location in 60-70% of cases, and the colon is the next most common location. S100 protein is strongly positive in IHC evaluation.

Gastrointestinal stromal tumor (GIST), gastrointestinal leiomyoma, and gastrointestinal tract neurofibroma are in the differential list.