Plexiform neurofibromas - neurofibromatosis type 1

Case contributed by Ammar Haouimi
Diagnosis almost certain

Presentation

Known case of NF1

Patient Data

Age: 30 years
Gender: Female
This study is a stack
Axial
T1
This study is a stack
Axial
T2
This study is a stack
Coronal
T2
This study is a stack
Coronal
STIR
This study is a stack
Sagittal
STIR
This study is a stack
Axial T1
C+ fat sat
This study is a stack
Coronal T1
C+ fat sat
This study is a stack
Axial
DWI
This study is a stack
Axial
ADC
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Info

The MRI sequences demonstrate bilateral cervical masses in the distribution of the nerve roots, extending from C3-C4 up to C6-C7. The largest masses are at C5-C6. with compression of the adjacent segment of the spinal cord from C3-C4 to C5-C6 level. They are of low signal on T1WI, high signal on T2WI with moderate and heterogeneous enhancement on postcontrast sequences. Note vertebral scalloping mainly of C4, C5, and C6. 

Case Discussion

MRI features of bilateral plexiform neurofibromas in a patient with neurofibromatosis type 1

 Plexiform neurofibromas are considered as benign tumors of peripheral nerves (WHO grade I), arising from a proliferation of all neural elements. They are seen in approximately 30% of patients with NF1 and considered pathognomonic of this disease.

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