Acute hepatitis - starry sky appearance

Case contributed by Ismael J Nassar
Diagnosis almost certain

Presentation

Abdominal pain, diarrhea, pale stool and dark urine.

Patient Data

Age: 6 years
Gender: Female
ultrasound

The liver shows periportal thickening with starry sky appearance. Otherwise, it appears normal in size without evidence of focal lesion or biliary tree dilatation.

The gallbladder shows diffuse wall thickening.

Case Discussion

Laboratory findings included positive HAV AB IgM and elevated ALT, AST and clinical picture were consistent with the diagnosis of acute hepatitis A Hepatitis.

Starry sky appearance is a nonspecific sign that is encountered in many entities including:

  • Acute hepatitis (viral, parasitic)

  • Toxic shock syndrome

  • Neoplastic involvement (Burkitt's lymphoma, leukemia)

  • Fasting liver with depleted glycogen stores

  • Drug-induced, alcoholic

  • Autoimmune

  • Radiation

  • NASH (NonAlcoholic SteatoHepatitis)

  • Twin–twin transfusion

Diffuse gallbladder wall thickening is a result of many etiologies, hepatitis is considered one of the causes.

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