Alpha-1-antitrypsin deficiency

Case contributed by Dr Abdallah Alqudah



Patient Data

Age: 50 years old
Gender: Male

Pan-lobular emphysematous changes diffusely replacing the lower lobes of both lungs with very thin internal septa but no residual lung tissue seen. Similar, yet, less severe changes are seen in the medial lobe of the right lung where interspersed lung tissue seen.

Centrilobular and paraseptal emphysematous changes involving the upper lobes of both lungs.

Subsegmental area of consolidation with air bronchograms seen in the inferior segment of the lingula.

Case Discussion

Severe lower lobe predominant panlobular emphysematous changes with no residual lung tissue seen.  In such middle age patient, these changes may be secondary to alpha-1 antitrypsin deficiency. 

Correlation with lab results is to be done and added to this case.

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Case information

rID: 50561
Published: 11th Jan 2017
Last edited: 13th Jan 2017
System: Chest
Inclusion in quiz mode: Included

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