Amyotrophic lateral sclerosis

Case contributed by Dr Dalia Ibrahim

Presentation

Progressive muscle weakness through the last 2 years

Patient Data

Age: 35
Gender: Male
Modality: MRI

High signal intensity involves the precentral gyri and descends through the corticospinal tracts in the posterior aspects of internal capsule and brainstem. It elicits high signal at T2 , FLAIR WI & specifically highlighted on DWI.

Case Discussion

Diagnosis confirmed by EMG & NVC.

Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease.

The earliest MR manifestation is hyper intensity on T2WI in the corticospinal tracts, seen earliest in the internal capsule.

Diffusion-weighted imaging is also helpful in the diagnosis of amyotrophic lateral sclerosis

Iron deposition in the cortex is demonstrated as loss of signal, most evident on T2* weighted sequences.

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Case Information

rID: 31772
Case created: 27th Oct 2014
Last edited: 28th Nov 2016
Inclusion in quiz mode: Included

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