Amyotrophic lateral sclerosis

Case contributed by Dr Dalia Ibrahim


Progressive muscle weakness through the last 2 years

Patient Data

Age: 35
Gender: Male

High signal intensity involves the precentral gyri and descends through the corticospinal tracts in the posterior aspects of internal capsule and brainstem. It elicits high signal at T2 , FLAIR WI & specifically highlighted on DWI.

Case Discussion

Diagnosis confirmed by EMG & NVC.

Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease.

The earliest MR manifestation is hyper intensity on T2WI in the corticospinal tracts, seen earliest in the internal capsule.

Diffusion-weighted imaging is also helpful in the diagnosis of amyotrophic lateral sclerosis

Iron deposition in the cortex is demonstrated as loss of signal, most evident on T2* weighted sequences.

PlayAdd to Share

Case information

rID: 31772
Published: 27th Oct 2014
Last edited: 28th Nov 2016
Inclusion in quiz mode: Included

Updating… Please wait.

Alert accept

Error Unable to process the form. Check for errors and try again.

Alert accept Thank you for updating your details.