Chordoma - sacrum

Case contributed by A.Prof Frank Gaillard

Patient Data

Age: 84 yrs
Gender: Male
Modality: MRI

Heterogenous mass arising from the sacral vertebra, seen as predominantly hypointense on T1 and hyperintense on T2 with vivid contrast enhancement. Multiple non-enhancing hypointense areas represent matrix calcifications.

Case Discussion

84 year old man with a sacral chordoma.

Final Diagnosis:

Biopsy, sacral mass: Chordoma

Final Diagnosis Comment:

The sections show strands and clusters of atypical epithelioid cells within a myxoid matrix. The tumor cells have oval to round, occasionally spindled, hyperchromatic nuceli with occasional larger nuceli with irregular contours. The cells have a moderate amount of vacuolated eosinophilic cytoplasm. Well developed physaliferous cells are not found. An occasional mitotic figure is found. There is no necrosis. Overt cartilaginous or osteoid tissue is not found.

By immunohistochemistry, the tumor cells are strongly positive for keratin. They are positive for S100 and EMA. They are negative for PSA.

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Case Information

rID: 6177
Case created: 2nd May 2009
Last edited: 14th Jul 2016
Tag: spine
Inclusion in quiz mode: Included

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