84 year old man with a sacral chordoma.
Biopsy, sacral mass: Chordoma
Final Diagnosis Comment:
The sections show strands and clusters of atypical epithelioid cells within a myxoid matrix. The tumor cells have oval to round, occasionally spindled, hyperchromatic nuceli with occasional larger nuceli with irregular contours. The cells have a moderate amount of vacuolated eosinophilic cytoplasm. Well developed physaliferous cells are not found. An occasional mitotic figure is found. There is no necrosis. Overt cartilaginous or osteoid tissue is not found.
By immunohistochemistry, the tumor cells are strongly positive for keratin. They are positive for S100 and EMA. They are negative for PSA.