Creutzfeldt-Jakob disease (CJD)

Case contributed by Christof Igler ◉

Diagnosis certain

Diagnosis certain

Citation, DOI, disclosures and case data

Citation:

Igler C, Creutzfeldt-Jakob disease (CJD). Case study, Radiopaedia.org (Accessed on 01 Oct 2023) https://doi.org/10.53347/rID-41280

DOI:

https://doi.org/10.53347/rID-41280

Permalink:

https://radiopaedia.org/cases/41280

rID:

41280

Disclosures:

At the time the case was submitted for publication Christof Igler had no recorded disclosures.

View Christof Igler's current disclosures

Case published:

24 Nov 2015

Revisions:

24 times, by 3 contributors - see full revision history and disclosures

Systems:

Central Nervous System

Quiz mode:

Included

Presentation

Rapidly progressive dementia. No focal neurological deficits.

Patient Data

Age: 85 years

Gender: Male

From the case: Creutzfeldt-Jakob disease (CJD)

mri

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Asymmetric restricted cortical diffusion involving predominantly the left hemisphere.

The FLAIR shows multiple non-specific hyperintense white-matter lesions and a hyperintensity of the right thalamus.

Symmetrical cortical atrophy.

No pathological contrast enhancement.

Case Discussion

The cortical restricted diffusion on DWI gives the best clue to the diagnosis of CJD.

The diagnosis was confirmed by the German Prion Research Center in Goettingen.

Diagnostic markers:

14-3-3 protein positive
PrPSc positive
S100b elevated

The patient died shortly after the diagnosis.

1 article features images from this case

Creutzfeldt-Jakob disease

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