Creutzfeldt-Jakob disease (CJD)
Rapidly progressive dementia. No focal neurological deficits.
Loading Stack -
0 images remaining
Asymmetric restricted cortical diffusion involving predominantly the left hemisphere.
The FLAIR shows multiple non-specific hyperintense white-matter lesions and a hyperintensity of the right thalamus.
Symmetrical cortical atrophy.
The cortical restricted diffusion on DWI gives the best clue to the diagnosis of CJD.
The diagnosis was confirmed by the German Prion Research Center in Goettingen.
- 14-3-3 protein positive
- PrPSc positive
- S100b elevated
The patient died shortly after the diagnosis.