Creutzfeldt-Jakob disease (CJD)

Case contributed by Dr C. Igler


Rapidly progressive dementia. No focal neurological deficits.

Patient Data

Age: 83
Gender: Male

Asymmetric restricted cortical diffusion involving predominantly the left hemisphere.

The FLAIR shows multiple non-specific hyperintense white-matter lesions and a hyperintensity of the right thalamus.

Symmetrical cortical atrophy.

Case Discussion

The cortical restricted diffusion on DWI gives the best clue to the diagnosis of CJD.

The diagnosis was confirmed by the German Prion Research Center in Goettingen.

Diagnostic markers:

  • 14-3-3 protein positive
  • PrPSc positive
  • S100b elevated

The patient died shortly after the diagnosis.

PlayAdd to Share

Case information

rID: 41280
Published: 24th Nov 2015
Last edited: 16th Jul 2018
Inclusion in quiz mode: Included

Updating… Please wait.

Alert accept

Error Unable to process the form. Check for errors and try again.

Alert accept Thank you for updating your details.