Presentation
Seizures
Patient Data
![](https://prod-images-static.radiopaedia.org/images/20565646/7ab7b68197f84633abe17ab394b3aa_thumb.jpeg)
![This study is a stack](/packs/stack-YQKLCKBI.gif)
![](https://prod-images-static.radiopaedia.org/images/20565063/6a9412b49faa923ce28027bcf5d5a9_thumb.jpeg)
![This study is a stack](/packs/stack-YQKLCKBI.gif)
![](https://prod-images-static.radiopaedia.org/images/20564744/7ba5a64ff7e7bc4671b8aabd404799_thumb.jpeg)
![This study is a stack](/packs/stack-YQKLCKBI.gif)
![](https://prod-images-static.radiopaedia.org/images/20566029/2eaa5f683970db743a9f6e34482609_thumb.jpeg)
![This study is a stack](/packs/stack-YQKLCKBI.gif)
![](https://prod-images-static.radiopaedia.org/images/20564813/1f8bfa369cb11ef222a6116bc9c73b_thumb.jpeg)
![This study is a stack](/packs/stack-YQKLCKBI.gif)
![](https://prod-images-static.radiopaedia.org/images/20566906/07563cde5ceb27a3d9d9fcfeab7e87_thumb.jpeg)
![This study is a stack](/packs/stack-YQKLCKBI.gif)
![](https://prod-images-static.radiopaedia.org/images/20565646/7ab7b68197f84633abe17ab394b3aa_big_gallery.jpeg)
A left frontal region of low density is present with mass effect. A small curvilinear region of increased density is noted, which is of uncertain significance.
![](https://prod-images-static.radiopaedia.org/images/20569284/2076df39bcf30e31b51c18878e3d25_thumb.jpeg)
![This study is a stack](/packs/stack-YQKLCKBI.gif)
![](https://prod-images-static.radiopaedia.org/images/20567177/d9b797e456820aed3f5acd84f06e5a_thumb.jpeg)
![This study is a stack](/packs/stack-YQKLCKBI.gif)
![](https://prod-images-static.radiopaedia.org/images/20567118/6c0f88a8ccd34779505ea06f9c3625_thumb.jpeg)
![This study is a stack](/packs/stack-YQKLCKBI.gif)
![](https://prod-images-static.radiopaedia.org/images/20568630/73b702e211237a60a60b16379402fc_thumb.jpeg)
![This study is a stack](/packs/stack-YQKLCKBI.gif)
![](https://prod-images-static.radiopaedia.org/images/20567996/d7a1110c66f9375a31eb2632b375ce_thumb.jpeg)
![This study is a stack](/packs/stack-YQKLCKBI.gif)
![](https://prod-images-static.radiopaedia.org/images/20570470/96e81a6a5e019be92135bbabfabb2f_thumb.jpeg)
![This study is a stack](/packs/stack-YQKLCKBI.gif)
![](https://prod-images-static.radiopaedia.org/images/20568925/1e85604f0e181e1bbd8a66fb0ca3ef_thumb.jpeg)
![This study is a stack](/packs/stack-YQKLCKBI.gif)
![](https://prod-images-static.radiopaedia.org/images/20567141/ec71f0ac244ef5ed4f0717a1ba7fa4_thumb.jpeg)
![This study is a stack](/packs/stack-YQKLCKBI.gif)
![](https://prod-images-static.radiopaedia.org/images/20569808/fdcdd3ad604e88bef8207fd2a444c2_thumb.jpeg)
![This study is a stack](/packs/stack-YQKLCKBI.gif)
![](https://prod-images-static.radiopaedia.org/images/20570276/c467994cdd3f3a395eedfa50951ba4_thumb.jpeg)
![This study is a stack](/packs/stack-YQKLCKBI.gif)
![](https://prod-images-static.radiopaedia.org/images/20567211/1fbd069576009cfaace85c04a3a613_thumb.jpeg)
![This study is a stack](/packs/stack-YQKLCKBI.gif)
![](https://prod-images-static.radiopaedia.org/images/20567261/c04995c5483216d3d7806d05c2eb93_thumb.jpeg)
![This study is a stack](/packs/stack-YQKLCKBI.gif)
![](https://prod-images-static.radiopaedia.org/images/20569284/2076df39bcf30e31b51c18878e3d25_big_gallery.jpeg)
A large left frontal mass is demonstrated without enhancement, calcification, necrosis or hemorrhage.
Features favor a diffuse low grade glioma.
Case Discussion
The patient went on to have surgery.
Histology
The sections show features of a moderately cellular astrocytic tumor. The tumor cells have elongated, angulated and hyperchromatic nuclei. Some gemistocytes are noted, occupying about 5% of the cell population. 1 mitosis is seen. No microvascular proliferation or necrosis is present. There is no oligodendroglial component. The features are those of diffuse astrocytoma.
The tumor cells are p53 and IDH-1 positive (mutated). ATRX shows loss of staining (mutated). MGMT is negative (likely methylated). The topoisomerase index is about 3%.
Final diagnose
Astrocytoma, IDH-mutant (WHO Grade 2)