Large skull metastasis: follicular thyroid primary

Case contributed by A.Prof Frank Gaillard

MRI scan shows a large complex solid and cystic mass that erodes the skull and shows an intracranial extension.

Case Discussion

Final Diagnosis: Scalp lesion, core needle biopsy: Thyroid tissue, highly suspicious for metastatic follicular thyroid carcinoma.

The biopsy shows well differentiated thyroid tissue, with no cytologic features of papillary thyroid carcinoma. Thyroid differentiation is confirmed by immunohistochemical stains that show expression of thyroglobulin and TTF-1.

This should be considered to be metastatic follicular thyroid carcinoma until proven otherwise. If this patient has no history of previous thyroid surgery, then investigations to identify the site of origin of the tumor are needed. Possible sites include the thyroid gland, sites of potential aberrant localization of thyroid tissue (such as mediastinum), as well as ovarian germ cell tumor.

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Case information

rID: 5389
Published: 12th Jan 2009
Last edited: 16th Jul 2018
Inclusion in quiz mode: Included

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