Neurosarcoidosis

Case contributed by Frank Gaillard
Diagnosis almost certain

Presentation

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Patient Data

Age: 40 years
Gender: Male

MRI brain

mri
This study is a stack
Axial
T1
This study is a stack
Axial
T2
This study is a stack
Axial
FLAIR
This study is a stack
Axial
T1 C+
This study is a stack
Coronal
T1 C+
This study is a stack
Sagittal
T1 C+
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Info

Multiple patchy region of increased T2 signal are demonstrated associated with contrast enhancement. Some of the these are periventricular, some are subcortical and others are in the brainstem. 

MRI brain - 4 years later

mri
This study is a stack
Axial
FLAIR
This study is a stack
Axial
T1 C+
This study is a stack
Axial
T1
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Info

4 years later enhancement persists but has altered in appearance and distribution.

Case Discussion

This patient had systemic sarcoidosis diagnosed on histology from a lung biopsy. Changes are consistent with neurosarcoidosis. The presence of enhancement 4 years later strongly argues against demyelination. 

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