Osteomyelitis of the femur

Case contributed by Lam Van Le
Diagnosis certain

Presentation

Fever, swelling and pain in the right thigh. Limited movement of the right hip joint

Patient Data

Age: 35 years
Gender: Female
x-ray
Frontal
Lateral
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There is localized cortical thickening in the upper third of the right femur, accompanied by several areas of bone lysis. The margins of the lesions are irregular, and there is no significant periosteal reaction.

mri
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Coronal
STIR
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Coronal
T1
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Sagittal
T2
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Axial
T2
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Axial
STIR
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Axial
T1
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T1 fat
sat
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Axial
DWI
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Axial
ADC
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On the MRI, there is localized thickening with cortical destruction in the upper third of the right femur, suspected to contain a bony sequestrum. The lesion disrupts the cortical bone, creating a fistulous tract to the adjacent soft tissue, resulting in an abscess (diffusion restriction) in the vastus intermedius muscle.

Bone marrow edema and surrounding soft tissue swelling in the upper and middle thirds of the femur are also noted.

With different specimens

pathology
H&E
H&E
H&E
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Microscopic description (from left to right)

  • inflamed bone tissue: normal trabecular bone structure with infiltration of inflammatory cells and hemorrhage

  • soft tissue around the bone: normal striated muscle structure with inflammatory fibrous tissue

  • bone marrow: bone tissue with extensive infiltration of inflammatory cells

Conclusion: findings consistent with osteomyelitis

After 5 months of treatment

x-ray
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After 5 months of treatment, follow-up X-rays show a significant reduction in the lesions, with localized cortical thickening and bone sclerosis in the upper third of the femur, indicating a healing process. There are no longer any areas of bone lysis.

Case Discussion

The findings on x-ray and MRI are consistent with osteomyelitis of the femur with the formation of a sinus tract and an abscess in the adjacent vastus medialis soft tissue.

Microbiological testing of a specimen from the fluid surrounding the upper third of the femur yielded a positive result for Staphylococcus aureus. The patient was subsequently treated with abscess surgery and intravenous antibiotics. Clinical symptoms, blood tests, and imaging findings all showed significant improvement.

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