Presentation
Painful mass in the lower part of the left femur.
Patient Data
Age: 12 years
Gender: Male
From the case:
Osteosarcoma
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There is a bone tumor with a wide zone of transition, osteoid matrix and aggressive periosteal reaction (Codman triangle - arrow), at the distal left femur.
From the case:
Osteosarcoma
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Osteoblastic osteosarcoma: Malignant cells producing osteoid (dense, pink, amorphous intercellular material) is the histological hallmark of osteosarcoma.
Courtesy of Dr Mohammad Adib Houreih, Department of Pathology, Tishreen University, Lattakia, Syria
Case Discussion
The radiographic findings in this 12 year old patient are compatible with osteosarcoma.
Osteosarcoma is the second most common primary bone tumor after multiple myeloma:
- primary osteosarcoma: typically occurs in young patients (10-20 years) with 75% occurring before the age of 20
- secondary osteosarcoma: occurs in the elderly, usually secondary to malignant degeneration of Paget disease, extensive bone infarcts or post-radiotherapy for other conditions
The most important differential considerations include :
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