Pancreatic neuroendocrine tumour

Case contributed by Yaïr Glick
Diagnosis certain

Presentation

Abdominal pain, known diverticulosis - diverticulitis?

Patient Data

Age: 75 years
Gender: Female

Diverticula along the colon, numerous in the descending colon and innumerable in the sigmoid colon. No sign of acute inflammation.

Ovoid mass in the body of the pancreas measuring 7.4 x 5.7 x 5.4 (RL x AP x CC) cm with central stellate hypodensity, the very centre of which represents necrosis. The pancreatic artery passes through the mass and is not compressed or distorted by it. The mass compresses the pancreatic vein. The pancreatic tail is atrophic and the main pancreatic duct through it is dilated. Prominent vessels in the hepatogastric ligament.

Several small cystic lesions in the left hepatic lobe, the largest in segment 4b, measuring 2.4 cm in length. Irregular 10-mm focus of arterial enhancement in hepatic segment 7 - vascular shunt?

Numerous bilateral peripelvic cysts.

Case Discussion

Tumour markers were normal.
Underwent distal pancreatectomy and splenectomy.

Histopathology report:
Pancreatic well-differentiated neuroendocrine tumour, G2, confined to the pancreas
Tumour size 6.2 cm. Mitotic rate - 3 per 10 HPF (2 mm2). Ki67 - 10%. Proximal pancreatic, anterior and posterior margins are free of tumour. Angiovascular invasion not identified. Fourteen (14)  peripancreatic lymph nodes are free of tumour. Unremarkable spleen.
Comment: Immunohistochemical stains for chromogranin and synaptophysin are positive.
pTNM: pT3, N0.

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