Perineural spread of squamous cell carcinoma: infra-orbital nerve
PH of aggressive SCC right medial cheek excision. Now dysaesthesia right cheek/infra-orbital margin
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Subtle but definite asymmetrical swelling of the right infra-orbital nerve with subtle increase in T2 signal and definite enhancement. These changes do not obviously involve the cavernous sinus or other cranial nerves.
Perineural spread of SCC in the head and neck is difficult to detect on MRI and requires meticulous technique (including high resolution pre and post contrast), high index of suspicion and careful examination of the cranial nerves adjacent to the site of primary neoplasm. The significance of detection is that prognosis following excision of SCC diminishes substantially and aggressive treatment including radiotherapy is required. In this case there was excellent response to radiation therapy.
- 1. Carter JB, Johnson MM, Chua TL et-al. Outcomes of primary cutaneous squamous cell carcinoma with perineural invasion: an 11-year cohort study. JAMA Dermatol. 2013;149 (1): 35-41. doi:10.1001/jamadermatol.2013.746 - Pubmed citation
- 2. Schmults CD, Karia PS, Carter JB et-al. Factors predictive of recurrence and death from cutaneous squamous cell carcinoma: a 10-year, single-institution cohort study. JAMA Dermatol. 2013;149 (5): 541-7. doi:10.1001/jamadermatol.2013.2139 - Pubmed citation