Pituitary macroadenoma - null cell

Case contributed by A.Prof Frank Gaillard


Visual failure.

Patient Data

Age: Adult
Gender: Male


MRI demonstrates a large mostly solid enhancing mass enlarging the pituitary fossa and extending into the suprasellar cistern, elevating and compressing the optic chiasm. Central areas demonstrate cystic change with some intrinsic high T1 signal. 

Case Discussion


Sections show multiple fragments of a pituitary adenoma, sclerotic stroma, and a few bony chips. The tumour cells are uniform and are laid in sheets and acini. The cytoplasm is amphophilic. There are no atypical features identified. The reticulin stain confirms the loss of acinar structure. No normal pituitary tissue is identified in the vicinity of the tumour. Immunohistochemistry for ACTH, prolactin, growth hormone, TSH, FSH and LH is negative.

Final diagnosis: Nonfunctioning (null cell) pituitary adenoma.

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Case information

rID: 5562
Published: 5th Feb 2009
Last edited: 16th Jul 2018
Inclusion in quiz mode: Included

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