Anti-MOG associated encephalomyelitis falls under the umbrella of neuromyelitis optica spectrum disorder (NMOSD) which is the target of rapidly developing research.

Despite a predominance of anti-MOG encephalomyelitis in children and young adults ¹, this case demonstrates occurrence in an older individual, which caused a diagnostic dilemma.

This case also demonstrates the benefit of the 3 tesla scanner in the diagnosis of this disease, which was capable of demonstrating multiple imaging features that are useful in distinguishing this entity from other demyelinating diseases (e.g. MS):

• large, confluent lesions
• smooth confluent periependymal involvement
• more extensive involvement of the corpus callosum (especially its ependymal surface)
• diencephalic involvement