The patient went on to have a resection.
Histology
MICROSCOPIC DESCRIPTION: The sections show features of a densely cellular astrocytic tumour. The tumour cells have hyperchromatic and pleomorphic nuclei. Some neoplastic gemistocytes are present. Scattered mitotic figures are identified. There are foci of microvascular proliferation. Areas of palisaded necrosis are present. No oligodendroglial component is seen. The features are those of glioblastoma. Small numbers of tumour cells are p53 positive. IDH1-R132H immunostain is negative. ATRX shows no loss of staining (non-mutated).
FINAL DIAGNOSIS: glioblastoma, IDH-wild-type (WHO Grade IV).
Treatment
The patient was commenced on routine Stupp protocol.