The 5-F rule refers to risk factors for the development of cholelithiasis in the event of upper abdominal pain:
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fair: more prevalent in the Caucasian population 1
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fat: BMI >30 kg/m2 and hyperlipidemia 3
- female
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fertile: one or more children
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forty: age ≥40 years
- cholelithiasis can occur in young patients with a positive family history; in such cases, the 'familial' factor can substitute for the 'forty' factor 2
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- 1. Pavel S, Thijs CT, Potocky V, et al. risk of gallstone formation. J. Epidemiol. Community Health [Internet]. 1992;46(4):425–7 [cited 2013 Nov 12]. Pubmed citation
- 2. Bass G, Gilani SNS, Walsh TN. Validating the 5Fs mnemonic for cholelithiasis: time to include family history. Postgrad. Med. J. [Internet]. 2013; 89(1057):638–41. [cited 2013 Nov 12] Postgraduate Medical Journal citation
- 3. Shih-Chang Hung, Kuan-Fu Liao, Shih-Wei Lai, et al. Risk factors associated with symptomatic cholelithiasis in Taiwan: a population-based study. (2011) BMC Gastroenterology. 11 (1): 1. doi:10.1186/1471-230X-11-111 - Pubmed
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