Angiosarcomas, are the most aggressive of the three, frequently having metastases at the time of diagnosis (and there carrying an extremely poor prognosis), and often having local recurrences.
They account for less than 1% of all sarcomas and are more frequently seen in males (M:F = 2:1) except when seen in the setting of post-mastectomy lymphoedema which is clearly more common in women and is known as Stewart-Treves syndrome.
The malignant cells express morphological and functional properties of endothelial cells. The tumours can be multicentric with haemorrhage and necrosis being common.
Location specific lesions
- hepatic angiosarcoma 2
- breast angiosarcoma 5
- cutaneous angiosarcoma 3
- musculoskeletal angiosarcoma
- cardiac angiosarcoma
- primary angiosarcoma of spleen
- pulmonary angiosarcoma (can be primary or metastatic) 4
- 1. Murphey MD, Fairbairn KJ, Parman LM et-al. From the archives of the AFIP. Musculoskeletal angiomatous lesions: radiologic-pathologic correlation. Radiographics. 1995;15 (4): 893-917. Radiographics (abstract) - Pubmed citation
- 2. Peterson MS, Baron RL, Rankin SC. Hepatic angiosarcoma: findings on multiphasic contrast-enhanced helical CT do not mimic hepatic hemangioma. AJR Am J Roentgenol. 2000;175 (1): 165-70. AJR Am J Roentgenol (full text) - Pubmed citation
- 3. Rich AL, Berman P. Cutaneous angiosarcoma presenting as an unusual facial bruise. Age Ageing. 2004;33 (5): 512-4. doi:10.1093/ageing/afh171 - Pubmed citation
- 4. Patel AM, Ryu JH. Angiosarcoma in the lung. Chest. 1993;103 (5): 1531-5. doi:10.1378/chest.103.5.1531 - Pubmed citation
- 5. Sanders LM, Groves AC, Schaefer S. Cutaneous angiosarcoma of the breast on MRI. AJR Am J Roentgenol. 2006;187 (2): W143-6. doi:10.2214/AJR.05.1940 - Pubmed citation