Angiosarcoma

Last revised by Yaïr Glick on 26 Oct 2024

Angiosarcomas (like hemangiopericytomas and hemangioendotheliomas) are tumors that arise from vascular structures. They are typically difficult to distinguish from one another on imaging alone.

Angiosarcomas are the most aggressive of the three, frequently having metastases at the time of diagnosis (and therefore carrying an extremely poor prognosis), and often recur locally. 

Epidemiology

They account for less than 1% of all sarcomas and are more frequently seen in males (M:F = 2:1). The exception is Stewart-Treves syndrome, a complication of protracted post-mastectomy lymphedema, which is obviously more common in women.

Pathology

The malignant cells express morphological and functional properties of endothelial cells. The tumors can be multicentric with hemorrhage and necrosis being common.

Location-specific lesions
Associations

Cases and figures

  • Case 1: pulmonary angiosarcoma
  • Case 2: adrenal angiosarcoma
  • Case 3: hepatic angiosarcoma
  • Case 4: breast angiosarcoma (MRI)
  • Case 5: right atrial angiosarcoma
  • Case 6: uterine angiosarcoma metastases
  • Case 7: metastatic soft tissue angiosarcoma
  • Case 8: pleural epithelioid angiosarcoma
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